Acute toxicity testing

1. Importance of acute toxicity testing

Using of chemicals to improve human life is very popular in the world. Besides their benefits, there are also many potential negative effects on people and the environment. Nowadays, many countries or international organizations develop laws and rules for chemical classification and labeling. With the large number of available chemicals, the specific rules for all chemicals are not simple for each one. It is important to provide information indicating the use of chemical of determination and their hazards. Through hazard definitions, a chemical may be dangerous in one country, but not in others, or a substance that can cause cancer in one country, but not in others.

With the international trade of chemistry, and the need to develop national programs ensuring safe use, transport, reclaim and disposal, it is recognized that an international harmonization approach to classification and labeling will provide the basis for such programs. Once, the countries have information on the chemicals they import or produce in their countries, the infrastructure to control chemical exposure, protect people and the environment can be established. Therefore, the reasons for setting a harmonized goal are quite large. And the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) has met those requirements. The GHS enhances the protection of human health and the environment by providing an international system of hazard connection. The GHS provides an accreditation rule for countries without a classifying system, reducing the need for chemical testing and evaluation. The GHS system provides harmonized standards for the classification of substances and complex substances based on human health, the environment and physical hazards; Harmonious hazard communicationthrough labelling and Safety Data Sheets (SDS).

In Vietnam, the Government's Decree No. 91/2016 / ND-CP of July 1, 2016, on management of insecticidal and germicidal chemicals and preparations for household and medical use. According to the regulations of Circular No. 21/2015 / TT-BNNPTNT dated June 8, 2015 of the Ministry of Agriculture and Rural Development on Plant protection drug, regulations on management of plant protection drugs include: registration; assay; production and trade; import export; quality check; certificate of conformity and announcement of conformity; preservation and transportation; use; labeling; packaging; advertisement; reclaim and destruction of plant protection drugs in Vietnam - this Circular is applied to domestic and foreign organizations and individuals conducting activities related to plant protection drugs in Vietnam.

Toxicity test provides the warning information of the risk of adverse health effects upon human exposure, adversely affecting the environment and the organisms where these products are used. This is the first step in establishing a dose in clinical testing and may provide initial information on the toxicity of the testing sample. According to the results of this test, the sample is classified as acute toxic chemical based on the "Global Harmonized System (GHS) for classification and labeling of acute toxic chemicals and OECD guidelines. Therefore, the product's acute toxicity test is the first step in finding out an acute toxics, and it is also the initial step in registering drugs for plant protective drug manufacturers.

2. Toxicity testing at National Institute for Food Control (hereinafter referred to as NIFC)

The parameters of toxicity testing performed by the National Insitute for Food Control consist of:

- Acute toxicity: 

  • Acute Oral Toxicity (LD50)
  • Acute Dermal Toxicity (LD50)
  • Acute Inhalation Toxicity (LC50)
  • Acute Eye Irritation/Corrosion
  • Acute Dermal Irritation /Corrosion
  • Allergy/ Sensitization Test

- Ecological toxicity:

  • Fish, Acute Toxicity Test (LC50)
  • Earthworm, Acute Toxicity Tests (LC50)
  • Honeybees, Acute Contact Toxicity Test (LD50)
  • Honeybees, Acute Oral Toxicity Test (LD50)
  • Avian Acute Oral Toxicity Test (LD50)

In addition, we do research on acute toxicity and semi-chronic toxicity and carcinogenic, mutagenic possibility of chemicals or finished chemical products.

3. Why choose the NIFC

  • The NIFC is a testing agency accredited with ISO/IEC 17025:2017 specifying the general requirements for the competence, impartiality and consistent operation of laboratories.
  • The NIFC is designated by the Ministry of Health, the Ministry of Industry and Trade, and the Ministry of Agriculture and Rural Development as a food testing unit to serve state management of food safety, animal feed, and fertilizer.

Acute toxicity testing for plant protection drug

Contact:

  • Head office: Science and Technology Service Center – National Institute for Food Control 

Add: No. 65 Pham Than Duat Str., Mai Dich Ward., Cau Giay Dist., Ha Noi

Tel: (+84) 24.32262251/ Hotline: (+84) 947.744.411 (Mr. Luyen), (+84) 912.995.096 (Mr. Kien)

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  • Representative office in Ho Chi Minh City

Add: Tan Cang - Cat Lai Port, Room A102, Gate B Cat Lai Port,1295B Nguyen Thi Dinh Street, Cat Lai Ward, District 2, Ho Chi Minh City

Tel: (+84) 28.37.400.888/ Hotline: (+84) 918.959.678 (Mr. Nghi)    

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  • Representative office in Hai Phong 

Add: No. 1 Ngo Quyen, Hai Phong City

Tel: (+84) 225.8830316/ Hotline: (+84) 983.300.226 (Ms. Thuong)

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